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Is there science behind pregnancy brain?
Penny found 20 sources
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11 peer-reviewed research articles
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Is “Pregnancy Brain” Real? What Science Says
Pregnancy brain—the idea that memory and thinking skills change during pregnancy—is supported by scientific evidence, but the story is more nuanced than the popular myth suggests. Research shows that pregnancy does cause real, measurable changes in the brain, but the impact on daily life is usually mild and varies from person to person.
Brain Changes During Pregnancy: What Happens?
Profound hormonal and structural changes occur in the brain
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Brain imaging studies show that pregnancy leads to reductions in gray matter volume (the part of the brain involved in processing and memory), especially in areas related to social cognition and emotional processing.
Neuroanatomical changes observed over the course of a human pregnancy | Nature NeurosciencePregnancy is a period of profound hormonal and physiological changes experienced by millions of women annually, yet the neural changes unfolding in the maternal brain throughout gestation are not well studied in humans.Read full articleSource: NatureBrain changes observed during pregnancy | National Institutes of Health (NIH)This triggers profound changes throughout the body, including in the brain. Scans of the brain before and after pregnancy have shown a reduction in gray matter volume. Gray matter contains the bodies of neurons, synapses, and glial cells, and is found mainly in the brain’s surface layer, ...Pregnancy leads to long-lasting changes in human brain structure | Nature NeuroscienceNature Neuroscience - The authors show that pregnancy involves substantial and consistent structural changes in the human brain, primarily located in regions subserving social cognition. These...Read full articleSource: NatureMapping the effects of pregnancy on resting state brain activity, white matter microstructure, neural metabolite concentrations and grey matter architecture | Nature CommunicationsTaken together, our anatomical and resting state MRI data thus indicate that pregnancy is associated with a structural and functional plasticity within the DMN, suggesting that becoming a mother alters the baseline state of the brain.Read full articleSource: NatureChange in Brain Size during and after Pregnancy: Study in Healthy Women and Women with Preeclampsia - PMCRESULTS: Both the healthy and preeclamptic groups had a reduction in brain size during pregnancy that was maximal at term and that reversed by 6 months after delivery. The ventricular size showed a corresponding increase in size during pregnancy and a decrease in size after delivery.What happens to the brain during pregnancy? - PMCWe are more than just vessels for ... and psychological change in our brain health. Fortunately, there is growing momentum in the field. The academic journal Nature Neuroscience recently highlighted an fMRI paper studying pregnancy brain changes on its front cover, public ...
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These changes are thought to help prepare the brain for motherhood, such as responding to a baby’s needs and forming attachment.
Pregnancy leads to long-lasting changes in human brain structure | Nature NeuroscienceNature Neuroscience - The authors show that pregnancy involves substantial and consistent structural changes in the human brain, primarily located in regions subserving social cognition. These...Read full articleSource: NatureWhat happens to the brain during pregnancy? - PMCWe are more than just vessels for ... and psychological change in our brain health. Fortunately, there is growing momentum in the field. The academic journal Nature Neuroscience recently highlighted an fMRI paper studying pregnancy brain changes on its front cover, public ...
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White matter (the brain’s communication network) may actually become more organized during pregnancy.
Brain changes observed during pregnancy | National Institutes of Health (NIH)This triggers profound changes throughout the body, including in the brain. Scans of the brain before and after pregnancy have shown a reduction in gray matter volume. Gray matter contains the bodies of neurons, synapses, and glial cells, and is found mainly in the brain’s surface layer, ...Mapping the effects of pregnancy on resting state brain activity, white matter microstructure, neural metabolite concentrations and grey matter architecture | Nature CommunicationsTaken together, our anatomical and resting state MRI data thus indicate that pregnancy is associated with a structural and functional plasticity within the DMN, suggesting that becoming a mother alters the baseline state of the brain.Read full articleSource: Nature
Cognitive Function: What Does the Research Show?
Memory and attention may be affected, but changes are subtle
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Meta-analyses and reviews find that pregnant people, especially in the third trimester, may experience small declines in memory, attention, and executive function compared to non-pregnant people.
"Pregnancy Brain": A Review of Cognitive Changes in Pregnancy and Postpartum - PubMedHowever, studies in humans are ... Nevertheless, the consensus among researchers is that pregnancy does confer deficits in working memory relative to nonpregnant controls....Read full articleSource: PubMedHormones and Cognitive Functioning During Late Pregnancy and Postpartum: A Longitudinal Study - PMCThis longitudinal study investigated the possible influence of estradiol (E2), progesterone (P), testosterone (T), cortisol (CORT), and prolactin (PRL) levels on cognitive functioning during late pregnancy and the early postpartum period. The ...The effect of pregnancy on maternal cognition | Scientific ReportsA recently published review of ... there is little agreement on the type and the degree of memory impairment37. Cognitive performance seems to be diminished rather than enhanced in humans, whereas animal research overwhelmingly supports enhanced memory function during ...Read full articleSource: NatureNeurophysiological and cognitive changes in pregnancy - ScienceDirectThe hormonal fluctuations in pregnancy drive a wide range of adaptive changes in the maternal brain. These range from specific neurophysiological chan…Read full articleSource: sciencedirect.comCognitive impairment during pregnancy: a meta-analysis - PubMedWe aimed to determine whether pregnancy is associated with objective declines in cognitive functioning, and to assess the progression of any declines during pregnancy. Study design: We undertook a meta-analysis, applying a random effects model, of 20 studies that have reported quantitative relationships between pregnancy and changes in cognition.Read full articleSource: PubMed
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The most consistent findings are in “working memory” (holding and manipulating information in your mind) and verbal memory.
"Pregnancy Brain": A Review of Cognitive Changes in Pregnancy and Postpartum - PubMedHowever, studies in humans are ... Nevertheless, the consensus among researchers is that pregnancy does confer deficits in working memory relative to nonpregnant controls....Read full articleSource: PubMedHormones and Cognitive Functioning During Late Pregnancy and Postpartum: A Longitudinal Study - PMCThis longitudinal study investigated the possible influence of estradiol (E2), progesterone (P), testosterone (T), cortisol (CORT), and prolactin (PRL) levels on cognitive functioning during late pregnancy and the early postpartum period. The ...The effect of pregnancy on maternal cognition | Scientific ReportsA recently published review of ... there is little agreement on the type and the degree of memory impairment37. Cognitive performance seems to be diminished rather than enhanced in humans, whereas animal research overwhelmingly supports enhanced memory function during ...Read full articleSource: NatureNeurophysiological and cognitive changes in pregnancy - ScienceDirectThe hormonal fluctuations in pregnancy drive a wide range of adaptive changes in the maternal brain. These range from specific neurophysiological chan…Read full articleSource: sciencedirect.comBrain plasticity in pregnancy and the postpartum period: links to maternal caregiving and mental health - PMCPregnancy and the postpartum period involve numerous physiological adaptations that enable the development and survival of the offspring. A distinct neural plasticity characterizes the female brain during this period, and dynamic structural and ...
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However, the size of these changes is generally small, and most people function well in daily life.
"Pregnancy Brain": A Review of Cognitive Changes in Pregnancy and Postpartum - PubMedHowever, studies in humans are ... Nevertheless, the consensus among researchers is that pregnancy does confer deficits in working memory relative to nonpregnant controls....Read full articleSource: PubMedHormones and Cognitive Functioning During Late Pregnancy and Postpartum: A Longitudinal Study - PMCThis longitudinal study investigated the possible influence of estradiol (E2), progesterone (P), testosterone (T), cortisol (CORT), and prolactin (PRL) levels on cognitive functioning during late pregnancy and the early postpartum period. The ...Cognitive impairment during pregnancy: a meta-analysis - PubMedWe aimed to determine whether pregnancy is associated with objective declines in cognitive functioning, and to assess the progression of any declines during pregnancy. Study design: We undertook a meta-analysis, applying a random effects model, of 20 studies that have reported quantitative relationships between pregnancy and changes in cognition.Read full articleSource: PubMed
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Some studies find no significant changes, and others suggest that the brain may reorganize to enhance certain skills, like social cognition.
The effect of pregnancy on maternal cognition | Scientific ReportsA recently published review of ... there is little agreement on the type and the degree of memory impairment37. Cognitive performance seems to be diminished rather than enhanced in humans, whereas animal research overwhelmingly supports enhanced memory function during ...Read full articleSource: NatureNeurophysiological and cognitive changes in pregnancy - ScienceDirectThe hormonal fluctuations in pregnancy drive a wide range of adaptive changes in the maternal brain. These range from specific neurophysiological chan…Read full articleSource: sciencedirect.comWhat happens to the brain during pregnancy? - PMCWe are more than just vessels for ... and psychological change in our brain health. Fortunately, there is growing momentum in the field. The academic journal Nature Neuroscience recently highlighted an fMRI paper studying pregnancy brain changes on its front cover, public ...Cognitive impairment during pregnancy: a meta-analysis - PubMedWe aimed to determine whether pregnancy is associated with objective declines in cognitive functioning, and to assess the progression of any declines during pregnancy. Study design: We undertook a meta-analysis, applying a random effects model, of 20 studies that have reported quantitative relationships between pregnancy and changes in cognition.Read full articleSource: PubMedBrain plasticity in pregnancy and the postpartum period: links to maternal caregiving and mental health - PMCPregnancy and the postpartum period involve numerous physiological adaptations that enable the development and survival of the offspring. A distinct neural plasticity characterizes the female brain during this period, and dynamic structural and ...
Why Do These Changes Happen?
Hormones and adaptation for motherhood
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Dramatic increases in hormones like estrogen, progesterone, and cortisol during pregnancy are believed to drive these brain changes.
Neuroanatomical changes observed over the course of a human pregnancy | Nature NeurosciencePregnancy is a period of profound hormonal and physiological changes experienced by millions of women annually, yet the neural changes unfolding in the maternal brain throughout gestation are not well studied in humans.Read full articleSource: NatureNeurophysiological and cognitive changes in pregnancy - ScienceDirectThe hormonal fluctuations in pregnancy drive a wide range of adaptive changes in the maternal brain. These range from specific neurophysiological chan…Read full articleSource: sciencedirect.comWhat happens to the brain during pregnancy? - PMCWe are more than just vessels for ... and psychological change in our brain health. Fortunately, there is growing momentum in the field. The academic journal Nature Neuroscience recently highlighted an fMRI paper studying pregnancy brain changes on its front cover, public ...Brain plasticity in pregnancy and the postpartum period: links to maternal caregiving and mental health - PMCPregnancy and the postpartum period involve numerous physiological adaptations that enable the development and survival of the offspring. A distinct neural plasticity characterizes the female brain during this period, and dynamic structural and ...
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These adaptations may help new parents bond with their baby and respond to their needs.
Pregnancy leads to long-lasting changes in human brain structure | Nature NeuroscienceNature Neuroscience - The authors show that pregnancy involves substantial and consistent structural changes in the human brain, primarily located in regions subserving social cognition. These...Read full articleSource: NatureWhat happens to the brain during pregnancy? - PMCWe are more than just vessels for ... and psychological change in our brain health. Fortunately, there is growing momentum in the field. The academic journal Nature Neuroscience recently highlighted an fMRI paper studying pregnancy brain changes on its front cover, public ...
Are the Changes Permanent?
Most changes are temporary
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Brain structure and cognitive function generally return to pre-pregnancy levels within months after birth.
Brain changes observed during pregnancy | National Institutes of Health (NIH)This triggers profound changes throughout the body, including in the brain. Scans of the brain before and after pregnancy have shown a reduction in gray matter volume. Gray matter contains the bodies of neurons, synapses, and glial cells, and is found mainly in the brain’s surface layer, ...Change in Brain Size during and after Pregnancy: Study in Healthy Women and Women with Preeclampsia - PMCRESULTS: Both the healthy and preeclamptic groups had a reduction in brain size during pregnancy that was maximal at term and that reversed by 6 months after delivery. The ventricular size showed a corresponding increase in size during pregnancy and a decrease in size after delivery.What happens to the brain during pregnancy? - PMCWe are more than just vessels for ... and psychological change in our brain health. Fortunately, there is growing momentum in the field. The academic journal Nature Neuroscience recently highlighted an fMRI paper studying pregnancy brain changes on its front cover, public ...
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Some structural changes may last longer, but their impact on thinking and memory is not fully understood.
Pregnancy leads to long-lasting changes in human brain structure | Nature NeuroscienceNature Neuroscience - The authors show that pregnancy involves substantial and consistent structural changes in the human brain, primarily located in regions subserving social cognition. These...Read full articleSource: NatureWhat happens to the brain during pregnancy? - PMCWe are more than just vessels for ... and psychological change in our brain health. Fortunately, there is growing momentum in the field. The academic journal Nature Neuroscience recently highlighted an fMRI paper studying pregnancy brain changes on its front cover, public ...
How Strong Is the Evidence?
The science is evolving, but the phenomenon is real
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There is clear evidence for physical changes in the brain during pregnancy.
Neuroanatomical changes observed over the course of a human pregnancy | Nature NeurosciencePregnancy is a period of profound hormonal and physiological changes experienced by millions of women annually, yet the neural changes unfolding in the maternal brain throughout gestation are not well studied in humans.Read full articleSource: NatureBrain changes observed during pregnancy | National Institutes of Health (NIH)This triggers profound changes throughout the body, including in the brain. Scans of the brain before and after pregnancy have shown a reduction in gray matter volume. Gray matter contains the bodies of neurons, synapses, and glial cells, and is found mainly in the brain’s surface layer, ...Pregnancy leads to long-lasting changes in human brain structure | Nature NeuroscienceNature Neuroscience - The authors show that pregnancy involves substantial and consistent structural changes in the human brain, primarily located in regions subserving social cognition. These...Read full articleSource: NatureMapping the effects of pregnancy on resting state brain activity, white matter microstructure, neural metabolite concentrations and grey matter architecture | Nature CommunicationsTaken together, our anatomical and resting state MRI data thus indicate that pregnancy is associated with a structural and functional plasticity within the DMN, suggesting that becoming a mother alters the baseline state of the brain.Read full articleSource: NatureChange in Brain Size during and after Pregnancy: Study in Healthy Women and Women with Preeclampsia - PMCRESULTS: Both the healthy and preeclamptic groups had a reduction in brain size during pregnancy that was maximal at term and that reversed by 6 months after delivery. The ventricular size showed a corresponding increase in size during pregnancy and a decrease in size after delivery.What happens to the brain during pregnancy? - PMCWe are more than just vessels for ... and psychological change in our brain health. Fortunately, there is growing momentum in the field. The academic journal Nature Neuroscience recently highlighted an fMRI paper studying pregnancy brain changes on its front cover, public ...
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Evidence for cognitive changes is mixed: some studies show mild declines, others show no effect, and some suggest benefits in specific areas.
"Pregnancy Brain": A Review of Cognitive Changes in Pregnancy and Postpartum - PubMedHowever, studies in humans are ... Nevertheless, the consensus among researchers is that pregnancy does confer deficits in working memory relative to nonpregnant controls....Read full articleSource: PubMedHormones and Cognitive Functioning During Late Pregnancy and Postpartum: A Longitudinal Study - PMCThis longitudinal study investigated the possible influence of estradiol (E2), progesterone (P), testosterone (T), cortisol (CORT), and prolactin (PRL) levels on cognitive functioning during late pregnancy and the early postpartum period. The ...The effect of pregnancy on maternal cognition | Scientific ReportsA recently published review of ... there is little agreement on the type and the degree of memory impairment37. Cognitive performance seems to be diminished rather than enhanced in humans, whereas animal research overwhelmingly supports enhanced memory function during ...Read full articleSource: NatureNeurophysiological and cognitive changes in pregnancy - ScienceDirectThe hormonal fluctuations in pregnancy drive a wide range of adaptive changes in the maternal brain. These range from specific neurophysiological chan…Read full articleSource: sciencedirect.comCognitive impairment during pregnancy: a meta-analysis - PubMedWe aimed to determine whether pregnancy is associated with objective declines in cognitive functioning, and to assess the progression of any declines during pregnancy. Study design: We undertook a meta-analysis, applying a random effects model, of 20 studies that have reported quantitative relationships between pregnancy and changes in cognition.Read full articleSource: PubMedBrain plasticity in pregnancy and the postpartum period: links to maternal caregiving and mental health - PMCPregnancy and the postpartum period involve numerous physiological adaptations that enable the development and survival of the offspring. A distinct neural plasticity characterizes the female brain during this period, and dynamic structural and ...
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Differences in study design, how memory is measured, and individual factors may explain why results vary.
The effect of pregnancy on maternal cognition | Scientific ReportsA recently published review of ... there is little agreement on the type and the degree of memory impairment37. Cognitive performance seems to be diminished rather than enhanced in humans, whereas animal research overwhelmingly supports enhanced memory function during ...Read full articleSource: NatureNeurophysiological and cognitive changes in pregnancy - ScienceDirectThe hormonal fluctuations in pregnancy drive a wide range of adaptive changes in the maternal brain. These range from specific neurophysiological chan…Read full articleSource: sciencedirect.comCognitive impairment during pregnancy: a meta-analysis - PubMedWe aimed to determine whether pregnancy is associated with objective declines in cognitive functioning, and to assess the progression of any declines during pregnancy. Study design: We undertook a meta-analysis, applying a random effects model, of 20 studies that have reported quantitative relationships between pregnancy and changes in cognition.Read full articleSource: PubMedBrain plasticity in pregnancy and the postpartum period: links to maternal caregiving and mental health - PMCPregnancy and the postpartum period involve numerous physiological adaptations that enable the development and survival of the offspring. A distinct neural plasticity characterizes the female brain during this period, and dynamic structural and ...
Putting It All Together: What Does This Mean for You?
- “Pregnancy brain” is not just a myth—real changes in brain structure and function do occur.
- Most people notice only mild, temporary changes in memory or focus, if any.
- These changes are part of the body’s adaptation to pregnancy and early parenting.
- If you have concerns about memory or thinking, it might be beneficial to discuss them with your OB/GYN, who can help rule out other causes like sleep deprivation, stress, or mood changes.
What to Know Moving Forward
- The experience of “pregnancy brain” is real for some, but not everyone will notice changes.
- Most cognitive changes are mild and temporary.
- Ongoing research continues to explore how and why these changes happen, and how they might benefit new parents.
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Peer-Reviewed Research
Published, peer-reviewed scientific studies from journals or databases.
1
Neuroanatomical changes observed over the course of a human pregnancy | Nature Neuroscience
Pregnancy is a period of profound hormonal and physiological changes experienced by millions of women annually, yet the neural changes unfolding in the maternal brain throughout gestation are not well studied in humans.
Read full article
Source:
Nature
3
Pregnancy leads to long-lasting changes in human brain structure | Nature Neuroscience
Nature Neuroscience - The authors show that pregnancy involves substantial and consistent structural changes in the human brain, primarily located in regions subserving social cognition. These...
Read full article
Source:
Nature
4
Mapping the effects of pregnancy on resting state brain activity, white matter microstructure, neural metabolite concentrations and grey matter architecture | Nature Communications
Taken together, our anatomical and resting state MRI data thus indicate that pregnancy is associated with a structural and functional plasticity within the DMN, suggesting that becoming a mother alters the baseline state of the brain.
Read full article
Source:
Nature
5
Change in Brain Size during and after Pregnancy: Study in Healthy Women and Women with Preeclampsia - PMC
RESULTS: Both the healthy and preeclamptic groups had a reduction in brain size during pregnancy that was maximal at term and that reversed by 6 months after delivery. The ventricular size showed a corresponding increase in size during pregnancy and a decrease in size after delivery.
6
What happens to the brain during pregnancy? - PMC
We are more than just vessels for ... and psychological change in our brain health. Fortunately, there is growing momentum in the field. The academic journal Nature Neuroscience recently highlighted an fMRI paper studying pregnancy brain changes on its front cover, public ...
7
"Pregnancy Brain": A Review of Cognitive Changes in Pregnancy and Postpartum - PubMed
However, studies in humans are ... Nevertheless, the consensus among researchers is that pregnancy does confer deficits in working memory relative to nonpregnant controls....
Read full article
Source:
PubMed
8
Hormones and Cognitive Functioning During Late Pregnancy and Postpartum: A Longitudinal Study - PMC
This longitudinal study investigated the possible influence of estradiol (E2), progesterone (P), testosterone (T), cortisol (CORT), and prolactin (PRL) levels on cognitive functioning during late pregnancy and the early postpartum period. The ...
9
The effect of pregnancy on maternal cognition | Scientific Reports
A recently published review of ... there is little agreement on the type and the degree of memory impairment37. Cognitive performance seems to be diminished rather than enhanced in humans, whereas animal research overwhelmingly supports enhanced memory function during ...
Read full article
Source:
Nature
10
Neurophysiological and cognitive changes in pregnancy - ScienceDirect
The hormonal fluctuations in pregnancy drive a wide range of adaptive changes in the maternal brain. These range from specific neurophysiological chan…
Read full article
Source:
sciencedirect.com
11
Cognitive impairment during pregnancy: a meta-analysis - PubMed
We aimed to determine whether pregnancy is associated with objective declines in cognitive functioning, and to assess the progression of any declines during pregnancy. Study design: We undertook a meta-analysis, applying a random effects model, of 20 studies that have reported quantitative relationships between pregnancy and changes in cognition.
Read full article
Source:
PubMed
12
Brain plasticity in pregnancy and the postpartum period: links to maternal caregiving and mental health - PMC
Pregnancy and the postpartum period involve numerous physiological adaptations that enable the development and survival of the offspring. A distinct neural plasticity characterizes the female brain during this period, and dynamic structural and ...
Exploring the influence of pregnancy on cognitive function in women: a systematic review - PMC
Notably, seven studies originated from Australia, of which four were rated as low quality. The aggregated findings suggest that pregnancy modestly affects verbal memory and attention compared to non-pregnant controls, with indications that this decline persists postnatally.
Exploring the influence of pregnancy on cognitive function in women: a systematic review | BMC Pregnancy and Childbirth | Full Text
Until recently, most evidence concerning pregnancy-related memory problems was anecdotal and relied on subjective reports [17, 18]. A significant body of empirical research has now accumulated to address the extent to which self-perceived memory changes reflect actual memory changes [7]. While many studies support the idea that memory is negatively impacted during pregnancy [6, 19,20,21,22,23], others have found no significant effects [24,25,26]. De Groot summarizes that the evidence for objective cognitive changes during pregnancy is “equivocal.” Given these mixed findings and the growing
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BioMed Central
Cognitive Reorganization during Pregnancy and the Postpartum Period: An Evolutionary Perspective - Marla V. Anderson, Mel D. Rutherford, 2012
Finally, recent studies investigating cognitive change in the postpartum period suggest that while performance on some cognitive tasks may be similar during pregnancy and the postpartum period, other cognitive tasks are differentially impacted by pregnancy and the postpartum period (prospective memory and processing speed); more research is needed in order to determine how these distinct reproductive phases influence cognition.
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SAGE Journals
Exploring the impact of pregnancy on cognitive function: a comparative study in a low-income setting | BMC Pregnancy and Childbirth | Full Text
Our preliminary analyses suggest that there is notable cognitive impairment associated with pregnancy. More attention and research in this aspect can contribute to better prenatal care and promote the well-being of pregnant women.
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BioMed Central
Cognitive impairment during pregnancy: a meta‐analysis - Davies - 2018 - Medical Journal of Australia - Wiley Online Library
We aimed to determine whether pregnancy is associated with objective declines in cognitive functioning, and to assess the progression of any declines during pregnancy. Study design: We undertook a meta-analysis, applying a random effects model, of 20 studies that have reported quantitative relationships between pregnancy and changes in cognition.
The effect of pregnancy on maternal cognition - PMC
A recently published review of ... there is little agreement on the type and the degree of memory impairment37. Cognitive performance seems to be diminished rather than enhanced in humans, whereas animal research overwhelmingly supports enhanced memory function during ...
Pregnancy and post partum: changes in cognition and mood - PubMed
A review of studies that have ... specific areas of cognitive changes during and after pregnancy, notably deficits in verbal learning and memory....
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PubMed
The expectant brain–pregnancy leads to changes in brain morphology in the early postpartum period - PMC
Nat Neurosci. 20:134–135. [DOI] [PubMed] [Google Scholar] Barrière DA, Ella A, Szeremeta F, Adriaensen H, Même W, Chaillou E, Migaud M, Même S, Lévy F, Keller M. 2021. Brain orchestration of pregnancy and maternal behavior in mice: a longitudinal morphometric study.
Clinical Guidelines & Professional Sources
Clinical recommendations from government, public health organizations, or professional medical provider associations.
2
Brain changes observed during pregnancy | National Institutes of Health (NIH)
This triggers profound changes throughout the body, including in the brain. Scans of the brain before and after pregnancy have shown a reduction in gray matter volume. Gray matter contains the bodies of neurons, synapses, and glial cells, and is found mainly in the brain’s surface layer, ...
Medical & Academic Institutions
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General Health & Web Sources
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